Where can I get compounded Compounded Sermorelin + Naltrexone (Sublingual Combo)?

Compounded Sermorelin + Naltrexone (Sublingual Combo) is available through licensed compounding pharmacies on the SlimionRX network. Visit slimionrx.com to find a pharmacy near you.

Compounded Sermorelin + Naltrexone (Sublingual Combo) Sermorelin 2 mg / Naltrexone HCl 4 mg per mL — Compounded Sublingual Liquid Patient Monograph

Patient education monograph for Compounded Sermorelin + Naltrexone (Sublingual Combo) (Sermorelin 2 mg / Naltrexone HCl 4 mg per mL), a compounded sublingual liquid. Learn how it works, how to use it, possible side effects, and find a licensed compounding pharmacy near you.

What is Compounded Sermorelin + Naltrexone (Sublingual Combo)?

This compounded combination preparation contains sermorelin 2 mg and naltrexone hydrochloride 4 mg per mL in a sublingual liquid base, prepared by a licensed compounding pharmacy pursuant to a valid individual patient prescription. It combines growth hormone-releasing hormone stimulation with low-dose naltrexone (LDN) immune modulation in a single sublingual preparation, designed for provider-directed wellness and integrative protocols. Compounded preparations are not FDA-approved. Formula developed in partnership with Richie's Specialty Pharmacy.

How does Compounded Sermorelin + Naltrexone (Sublingual Combo) work?

Sermorelin stimulates the anterior pituitary to release natural growth hormone by binding GHRH receptors — supporting anabolic, metabolic, and recovery effects mediated by IGF-1 downstream. Naltrexone at low doses transiently blocks opioid receptors for several hours, triggering a rebound increase in endogenous endorphins and enkephalins. This brief blockade is believed to reduce systemic inflammatory signaling and modulate immune function. The bedtime combination leverages the nocturnal GH secretion window while simultaneously engaging the LDN immune-modulating mechanism.

How to use Compounded Sermorelin + Naltrexone (Sublingual Combo)

Administer at bedtime on an empty stomach as directed by your prescriber. Place the dose under the tongue and hold for at least 60 seconds before swallowing. Avoid eating, drinking, or rinsing your mouth for at least 10 minutes after administration. Do not take within 4–6 hours of any opioid medication — naltrexone will precipitate opioid withdrawal. Follow your prescriber's schedule and do not adjust doses independently.

Compounded Sermorelin + Naltrexone (Sublingual Combo) side effects

From the sermorelin component: headache, flushing, dizziness, joint discomfort, and mild water retention may occur. From the naltrexone (LDN) component: vivid or unusual dreams, mild insomnia, and transient nausea are most commonly reported during the first 2–4 weeks of use and usually resolve with continued therapy. Report persistent, severe, or bothersome side effects to your prescriber.

Drug interactions with Compounded Sermorelin + Naltrexone (Sublingual Combo)

CRITICAL — Naltrexone component: Do not take within 4–6 hours of any opioid medication. Naltrexone will block opioid effects and can precipitate opioid withdrawal. Glucocorticoids may reduce sermorelin's efficacy. LDN may modulate the response to immunosuppressant medications — discuss with your prescriber if relevant. Disclose all medications including supplements to your provider.

How to store Compounded Sermorelin + Naltrexone (Sublingual Combo)

Refrigerate at 36°F–46°F (2°C–8°C). Do not freeze. Protect from light. Keep tightly closed. Use within the beyond-use date on the pharmacy label. Discard if the solution appears cloudy, discolored, or contains particles.

Precautions for Compounded Sermorelin + Naltrexone (Sublingual Combo)

Do not use if you are currently taking full-dose opioid medications — naltrexone is an opioid antagonist and will precipitate withdrawal. Do not use if active malignancy is present without explicit prescriber guidance (sermorelin component). Safety in pregnancy and breastfeeding has not been established. Use only under active prescriber supervision. Keep out of reach of children.

Frequently Asked Questions — Compounded Sermorelin + Naltrexone (Sublingual Combo)

What is Compounded Sermorelin + Naltrexone (Sublingual Combo)?: This compounded combination preparation contains sermorelin 2 mg and naltrexone hydrochloride 4 mg per mL in a sublingual liquid base, prepared by a licensed compounding pharmacy pursuant to a valid individual patient prescription. It combines growth hormone-releasing hormone stimulation with low-dose naltrexone (LDN) immune modulation in a single sublingual preparation, designed for provider-directed wellness and integrative protocols. Compounded preparations are not FDA-approved. Formula devel
How does Compounded Sermorelin + Naltrexone (Sublingual Combo) work?: Sermorelin stimulates the anterior pituitary to release natural growth hormone by binding GHRH receptors — supporting anabolic, metabolic, and recovery effects mediated by IGF-1 downstream. Naltrexone at low doses transiently blocks opioid receptors for several hours, triggering a rebound increase in endogenous endorphins and enkephalins. This brief blockade is believed to reduce systemic inflammatory signaling and modulate immune function. The bedtime combination leverages the nocturnal GH secr
How do I use Compounded Sermorelin + Naltrexone (Sublingual Combo)?: Administer at bedtime on an empty stomach as directed by your prescriber. Place the dose under the tongue and hold for at least 60 seconds before swallowing. Avoid eating, drinking, or rinsing your mouth for at least 10 minutes after administration. Do not take within 4–6 hours of any opioid medication — naltrexone will precipitate opioid withdrawal. Follow your prescriber's schedule and do not adjust doses independently.
What are the side effects of Compounded Sermorelin + Naltrexone (Sublingual Combo)?: From the sermorelin component: headache, flushing, dizziness, joint discomfort, and mild water retention may occur. From the naltrexone (LDN) component: vivid or unusual dreams, mild insomnia, and transient nausea are most commonly reported during the first 2–4 weeks of use and usually resolve with continued therapy. Report persistent, severe, or bothersome side effects to your prescriber.
Are there drug interactions with Compounded Sermorelin + Naltrexone (Sublingual Combo)?: CRITICAL — Naltrexone component: Do not take within 4–6 hours of any opioid medication. Naltrexone will block opioid effects and can precipitate opioid withdrawal. Glucocorticoids may reduce sermorelin's efficacy. LDN may modulate the response to immunosuppressant medications — discuss with your prescriber if relevant. Disclose all medications including supplements to your provider.
How should I store Compounded Sermorelin + Naltrexone (Sublingual Combo)?: Refrigerate at 36°F–46°F (2°C–8°C). Do not freeze. Protect from light. Keep tightly closed. Use within the beyond-use date on the pharmacy label. Discard if the solution appears cloudy, discolored, or contains particles.
What precautions should I know about Compounded Sermorelin + Naltrexone (Sublingual Combo)?: Do not use if you are currently taking full-dose opioid medications — naltrexone is an opioid antagonist and will precipitate withdrawal. Do not use if active malignancy is present without explicit prescriber guidance (sermorelin component). Safety in pregnancy and breastfeeding has not been established. Use only under active prescriber supervision. Keep out of reach of children.
Where can I get compounded Compounded Sermorelin + Naltrexone (Sublingual Combo)?: Compounded Sermorelin + Naltrexone (Sublingual Combo) is available through licensed compounding pharmacies on the SlimionRX network. Visit slimionrx.com to find a pharmacy near you.