Compounded Semaglutide (Sublingual) 9.15 mg / 0.5 mL — Compounded Sublingual Liquid Patient Monograph

What is Compounded Semaglutide (Sublingual)?

This compounded preparation contains semaglutide in a sublingual liquid base, prepared by a licensed compounding pharmacy pursuant to a valid individual patient prescription. It is used as part of a medically supervised weight management and metabolic health program. Compounded semaglutide is not an FDA-approved product — it is prepared under a prescriber's order for a specific patient.

How does Compounded Semaglutide (Sublingual) work?

Semaglutide is a GLP-1 receptor agonist that mimics the body's naturally occurring glucagon-like peptide-1 hormone. It acts on receptors in the brain and gut to reduce appetite, slow gastric emptying, and support feelings of fullness after eating. It also promotes insulin release in response to elevated blood sugar. The sublingual route is designed to facilitate absorption through the mucous membranes under the tongue.

How to use Compounded Semaglutide (Sublingual)

Place the prescribed dose under the tongue as directed by your prescriber. Hold the liquid there for the time instructed before swallowing. Do not eat, drink, or rinse your mouth immediately after administration. Follow your prescriber's dose escalation schedule — do not increase the dose on your own.

Compounded Semaglutide (Sublingual) side effects

Nausea, decreased appetite, constipation, diarrhea, and abdominal discomfort are most commonly reported, especially when starting or increasing the dose. These effects usually improve within a few weeks. Headache and fatigue may also occur. Report severe abdominal pain, persistent vomiting, or signs of dehydration to your prescriber immediately.

Drug interactions with Compounded Semaglutide (Sublingual)

Semaglutide may slow the absorption of other oral medications due to its effect on gastric emptying — allow extra time between this preparation and other oral drugs. Use caution with insulin or sulfonylureas (increased low blood sugar risk). Inform your prescriber of all medications, including thyroid drugs and blood thinners.

How to store Compounded Semaglutide (Sublingual)

Store as directed by the dispensing pharmacy. Many sublingual semaglutide preparations require refrigeration at 36°F–46°F (2°C–8°C) and protection from light. Do not freeze. Use within the beyond-use date printed on the label.

Precautions for Compounded Semaglutide (Sublingual)

Contact your prescriber immediately if you experience severe nausea, vomiting, or abdominal pain. Do not use if you have a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Use only under direct prescriber supervision as part of a comprehensive weight management program. Keep out of reach of children.

Frequently Asked Questions — Compounded Semaglutide (Sublingual)

What is Compounded Semaglutide (Sublingual)?

This compounded preparation contains semaglutide in a sublingual liquid base, prepared by a licensed compounding pharmacy pursuant to a valid individual patient prescription. It is used as part of a medically supervised weight management and metabolic health program. Compounded semaglutide is not an FDA-approved product — it is prepared under a prescriber's order for a specific patient.

How does Compounded Semaglutide (Sublingual) work?

Semaglutide is a GLP-1 receptor agonist that mimics the body's naturally occurring glucagon-like peptide-1 hormone. It acts on receptors in the brain and gut to reduce appetite, slow gastric emptying, and support feelings of fullness after eating. It also promotes insulin release in response to elevated blood sugar. The sublingual route is designed to facilitate absorption through the mucous membranes under the tongue.

How do I use Compounded Semaglutide (Sublingual)?

Place the prescribed dose under the tongue as directed by your prescriber. Hold the liquid there for the time instructed before swallowing. Do not eat, drink, or rinse your mouth immediately after administration. Follow your prescriber's dose escalation schedule — do not increase the dose on your own.

What are the side effects of Compounded Semaglutide (Sublingual)?

Nausea, decreased appetite, constipation, diarrhea, and abdominal discomfort are most commonly reported, especially when starting or increasing the dose. These effects usually improve within a few weeks. Headache and fatigue may also occur. Report severe abdominal pain, persistent vomiting, or signs of dehydration to your prescriber immediately.

Are there drug interactions with Compounded Semaglutide (Sublingual)?

Semaglutide may slow the absorption of other oral medications due to its effect on gastric emptying — allow extra time between this preparation and other oral drugs. Use caution with insulin or sulfonylureas (increased low blood sugar risk). Inform your prescriber of all medications, including thyroid drugs and blood thinners.

How should I store Compounded Semaglutide (Sublingual)?

Store as directed by the dispensing pharmacy. Many sublingual semaglutide preparations require refrigeration at 36°F–46°F (2°C–8°C) and protection from light. Do not freeze. Use within the beyond-use date printed on the label.

What precautions should I know about Compounded Semaglutide (Sublingual)?

Contact your prescriber immediately if you experience severe nausea, vomiting, or abdominal pain. Do not use if you have a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Use only under direct prescriber supervision as part of a comprehensive weight management program. Keep out of reach of children.

Where can I get compounded Compounded Semaglutide (Sublingual)?

Compounded Semaglutide (Sublingual) is available through licensed compounding pharmacies on the SlimionRX network. Visit slimionrx.com to find a pharmacy near you.