Compounded Semaglutide + NAD+ (Sublingual Combo) Semaglutide 6.1 mg / NAD+ 50 mg per 0.5 mL — Compounded Sublingual Liquid Patient Monograph

Patient education monograph for Compounded Semaglutide + NAD+ (Sublingual Combo) (Semaglutide 6.1 mg / NAD+ 50 mg per 0.5 mL), a compounded sublingual liquid. Learn how it works, how to use it, possible side effects, and find a licensed compounding pharmacy near you.

What is Compounded Semaglutide + NAD+ (Sublingual Combo)?

This compounded combination preparation contains semaglutide 6.1 mg and nicotinamide adenine dinucleotide (NAD+) 50 mg per 0.5 mL in a sublingual liquid base, prepared by a licensed compounding pharmacy pursuant to a valid individual patient prescription. It combines GLP-1 receptor agonism for appetite and metabolic control with NAD+ supplementation for cellular energy support, designed for provider-directed weight management and metabolic wellness programs. Compounded preparations are not FDA-approved products. Formula developed in partnership with Richie's Specialty Pharmacy.

How does Compounded Semaglutide + NAD+ (Sublingual Combo) work?

Semaglutide activates GLP-1 receptors in the brain and gut, suppressing appetite, slowing gastric emptying, and stimulating insulin secretion. NAD+ is a coenzyme essential for mitochondrial energy production, DNA repair, and sirtuin-pathway activation. NAD+ levels decline with age, obesity, and metabolic dysfunction — supplementation via sublingual delivery aims to support cellular energy metabolism and mitochondrial efficiency. The combination pairs weight management support with a cellular-level metabolic foundation, designed for comprehensive metabolic optimization.

How to use Compounded Semaglutide + NAD+ (Sublingual Combo)

Administer under the tongue as directed by your prescriber. Hold the preparation in place for at least 60 seconds before swallowing. Do not eat, drink, or rinse your mouth for at least 10 minutes after administration. Administer semaglutide doses on the same day each week (weekly dosing schedule). Follow your prescriber's complete protocol — do not alter doses independently.

Compounded Semaglutide + NAD+ (Sublingual Combo) side effects

Nausea, appetite suppression, constipation, and diarrhea are the most common effects from the semaglutide component. Flushing, transient headache, and mild fatigue may occur from the NAD+ component, particularly in the first few days. These effects are generally mild and transient. Report any severe abdominal pain, persistent vomiting, or signs of an allergic reaction to your prescriber immediately.

Drug interactions with Compounded Semaglutide + NAD+ (Sublingual Combo)

The semaglutide component slows gastric emptying and may delay absorption of co-administered oral medications. Use caution with concurrent insulin or sulfonylureas (hypoglycemia risk). NAD+ may interact with antivirals and niacin-based supplements — discuss with your prescriber. Alcohol substantially depletes NAD+ and should be minimized during therapy. Disclose all medications and supplements to your provider.

How to store Compounded Semaglutide + NAD+ (Sublingual Combo)

Refrigerate at 36°F–46°F (2°C–8°C). Do not freeze. Protect from light. Keep tightly closed and upright. Use within the beyond-use date on the pharmacy label. Do not use if the solution appears cloudy or discolored.

Precautions for Compounded Semaglutide + NAD+ (Sublingual Combo)

Contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (semaglutide component). Do not use if allergic to any component. Limited long-term clinical trial data exists for combined semaglutide + sublingual NAD+ — discuss benefit-risk with your prescriber. Use only under prescriber supervision. Keep out of reach of children.

Where to get compounded Compounded Semaglutide + NAD+ (Sublingual Combo)

Compounded Semaglutide + NAD+ (Sublingual Combo) is available through licensed compounding pharmacies on the SlimionRX network:

Benbrook pharmacy — Benbrook, TX

Frequently Asked Questions — Compounded Semaglutide + NAD+ (Sublingual Combo)

What is Compounded Semaglutide + NAD+ (Sublingual Combo)?: This compounded combination preparation contains semaglutide 6.1 mg and nicotinamide adenine dinucleotide (NAD+) 50 mg per 0.5 mL in a sublingual liquid base, prepared by a licensed compounding pharmacy pursuant to a valid individual patient prescription. It combines GLP-1 receptor agonism for appetite and metabolic control with NAD+ supplementation for cellular energy support, designed for provider-directed weight management and metabolic wellness programs. Compounded preparations are not FDA-a
How does Compounded Semaglutide + NAD+ (Sublingual Combo) work?: Semaglutide activates GLP-1 receptors in the brain and gut, suppressing appetite, slowing gastric emptying, and stimulating insulin secretion. NAD+ is a coenzyme essential for mitochondrial energy production, DNA repair, and sirtuin-pathway activation. NAD+ levels decline with age, obesity, and metabolic dysfunction — supplementation via sublingual delivery aims to support cellular energy metabolism and mitochondrial efficiency. The combination pairs weight management support with a cellular-lev
How do I use Compounded Semaglutide + NAD+ (Sublingual Combo)?: Administer under the tongue as directed by your prescriber. Hold the preparation in place for at least 60 seconds before swallowing. Do not eat, drink, or rinse your mouth for at least 10 minutes after administration. Administer semaglutide doses on the same day each week (weekly dosing schedule). Follow your prescriber's complete protocol — do not alter doses independently.
What are the side effects of Compounded Semaglutide + NAD+ (Sublingual Combo)?: Nausea, appetite suppression, constipation, and diarrhea are the most common effects from the semaglutide component. Flushing, transient headache, and mild fatigue may occur from the NAD+ component, particularly in the first few days. These effects are generally mild and transient. Report any severe abdominal pain, persistent vomiting, or signs of an allergic reaction to your prescriber immediately.
Are there drug interactions with Compounded Semaglutide + NAD+ (Sublingual Combo)?: The semaglutide component slows gastric emptying and may delay absorption of co-administered oral medications. Use caution with concurrent insulin or sulfonylureas (hypoglycemia risk). NAD+ may interact with antivirals and niacin-based supplements — discuss with your prescriber. Alcohol substantially depletes NAD+ and should be minimized during therapy. Disclose all medications and supplements to your provider.
How should I store Compounded Semaglutide + NAD+ (Sublingual Combo)?: Refrigerate at 36°F–46°F (2°C–8°C). Do not freeze. Protect from light. Keep tightly closed and upright. Use within the beyond-use date on the pharmacy label. Do not use if the solution appears cloudy or discolored.
What precautions should I know about Compounded Semaglutide + NAD+ (Sublingual Combo)?: Contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (semaglutide component). Do not use if allergic to any component. Limited long-term clinical trial data exists for combined semaglutide + sublingual NAD+ — discuss benefit-risk with your prescriber. Use only under prescriber supervision. Keep out of reach of children.
Where can I get compounded Compounded Semaglutide + NAD+ (Sublingual Combo)?: Compounded Semaglutide + NAD+ (Sublingual Combo) is available at compounding pharmacies on the SlimionRX network, including Benbrook pharmacy .