Promethazine PLO Gel 12.5–25 mg/g — Compounded Transdermal Gel Patient Monograph
Patient education monograph for Promethazine PLO Gel (12.5–25 mg/g), a compounded transdermal gel. Learn how it works, how to use it, possible side effects, and find a licensed compounding pharmacy near you.
What is Promethazine PLO Gel?
This compounded preparation contains promethazine hydrochloride in a Pluronic Lecithin Organogel (PLO) base, prepared by a licensed compounding pharmacy pursuant to an individual patient prescription. It is applied to the skin to help control nausea and vomiting when oral medication is not tolerated.
How does Promethazine PLO Gel work?
Promethazine is a first-generation antihistamine with dopamine receptor antagonist activity. It reduces nausea and vomiting by blocking dopamine receptors in the chemoreceptor trigger zone of the brain. In PLO gel form, the medication is designed to absorb through the skin into the bloodstream, though the degree of absorption varies between patients.
How to use Promethazine PLO Gel
Apply the prescribed amount of gel to the inner wrist or inner forearm as directed. Rotate the application site with each dose to reduce local irritation. Use only as often as prescribed — do not apply extra doses on your own. Wear gloves or wash hands thoroughly after applying.
Promethazine PLO Gel side effects
Drowsiness is the most common side effect and may be significant. Dry mouth, blurred vision, dizziness, and mild skin irritation at the application site may also occur. Avoid activities requiring alertness (such as driving) until you know how this medication affects you.
Drug interactions with Promethazine PLO Gel
Promethazine increases the sedating effect of opioids, benzodiazepines, sleep aids, muscle relaxants, and alcohol. Do not combine with other sedating medications without consulting your prescriber. It may also interact with MAOIs — tell your prescriber or pharmacist about all medications you are taking.
How to store Promethazine PLO Gel
Store at room temperature, 59°F–77°F (15°C–25°C). Protect from heat, direct sunlight, and freezing. PLO gel may liquefy if exposed to high temperatures — keep the container tightly closed and out of warm environments.
Precautions for Promethazine PLO Gel
Do not use in children under 2 years of age. May cause significant drowsiness — do not drive or operate machinery. Keep out of reach of children. Contact your prescriber immediately if you experience a severe allergic reaction, difficulty breathing, or unusual cardiac symptoms.
Frequently Asked Questions — Promethazine PLO Gel
- What is Promethazine PLO Gel?
- This compounded preparation contains promethazine hydrochloride in a Pluronic Lecithin Organogel (PLO) base, prepared by a licensed compounding pharmacy pursuant to an individual patient prescription. It is applied to the skin to help control nausea and vomiting when oral medication is not tolerated.
- How does Promethazine PLO Gel work?
- Promethazine is a first-generation antihistamine with dopamine receptor antagonist activity. It reduces nausea and vomiting by blocking dopamine receptors in the chemoreceptor trigger zone of the brain. In PLO gel form, the medication is designed to absorb through the skin into the bloodstream, though the degree of absorption varies between patients.
- How do I use Promethazine PLO Gel?
- Apply the prescribed amount of gel to the inner wrist or inner forearm as directed. Rotate the application site with each dose to reduce local irritation. Use only as often as prescribed — do not apply extra doses on your own. Wear gloves or wash hands thoroughly after applying.
- What are the side effects of Promethazine PLO Gel?
- Drowsiness is the most common side effect and may be significant. Dry mouth, blurred vision, dizziness, and mild skin irritation at the application site may also occur. Avoid activities requiring alertness (such as driving) until you know how this medication affects you.
- Are there drug interactions with Promethazine PLO Gel?
- Promethazine increases the sedating effect of opioids, benzodiazepines, sleep aids, muscle relaxants, and alcohol. Do not combine with other sedating medications without consulting your prescriber. It may also interact with MAOIs — tell your prescriber or pharmacist about all medications you are taking.
- How should I store Promethazine PLO Gel?
- Store at room temperature, 59°F–77°F (15°C–25°C). Protect from heat, direct sunlight, and freezing. PLO gel may liquefy if exposed to high temperatures — keep the container tightly closed and out of warm environments.
- What precautions should I know about Promethazine PLO Gel?
- Do not use in children under 2 years of age. May cause significant drowsiness — do not drive or operate machinery. Keep out of reach of children. Contact your prescriber immediately if you experience a severe allergic reaction, difficulty breathing, or unusual cardiac symptoms.
- Where can I get compounded Promethazine PLO Gel?
- Promethazine PLO Gel is available through licensed compounding pharmacies on the SlimionRX network. Visit slimionrx.com to find a pharmacy near you.