Naltrexone / Bupropion (LDN) Per prescriber order — Compounded Capsule Patient Monograph
Patient education monograph for Naltrexone / Bupropion (LDN) (Per prescriber order), a compounded capsule. Learn how it works, how to use it, possible side effects, and find a licensed compounding pharmacy near you.
What is Naltrexone / Bupropion (LDN)?
This compounded preparation contains naltrexone and/or bupropion formulated by a licensed pharmacy pursuant to an individual patient prescription for weight management support.
How does Naltrexone / Bupropion (LDN) work?
Naltrexone blocks opioid receptors in the brain's reward center while bupropion acts on dopamine and norepinephrine pathways. Together, they reduce cravings and the rewarding response to food, helping to support calorie reduction over time.
How to use Naltrexone / Bupropion (LDN)
Take as directed on your prescription label. Do not crush, chew, or split capsules unless instructed. Take with food to minimize stomach upset.
Naltrexone / Bupropion (LDN) side effects
Nausea is the most common side effect. Headache, constipation, dizziness, insomnia, and dry mouth may also occur. Starting slowly and taking with food can significantly reduce nausea in the early weeks.
Drug interactions with Naltrexone / Bupropion (LDN)
Do not take with opioid medications — naltrexone will block their effect and can precipitate withdrawal. Bupropion interacts with MAOIs (allow 14 days between), certain antidepressants, and medications that lower the seizure threshold. Avoid alcohol.
How to store Naltrexone / Bupropion (LDN)
Store at room temperature, away from heat, moisture, and direct light. Keep in the original container with the lid tightly closed.
Precautions for Naltrexone / Bupropion (LDN)
Do not take if you have uncontrolled high blood pressure, seizure disorder, or if you are currently using opioids. Keep out of reach of children.
Frequently Asked Questions — Naltrexone / Bupropion (LDN)
- What is Naltrexone / Bupropion (LDN)?
- This compounded preparation contains naltrexone and/or bupropion formulated by a licensed pharmacy pursuant to an individual patient prescription for weight management support.
- How does Naltrexone / Bupropion (LDN) work?
- Naltrexone blocks opioid receptors in the brain's reward center while bupropion acts on dopamine and norepinephrine pathways. Together, they reduce cravings and the rewarding response to food, helping to support calorie reduction over time.
- How do I use Naltrexone / Bupropion (LDN)?
- Take as directed on your prescription label. Do not crush, chew, or split capsules unless instructed. Take with food to minimize stomach upset.
- What are the side effects of Naltrexone / Bupropion (LDN)?
- Nausea is the most common side effect. Headache, constipation, dizziness, insomnia, and dry mouth may also occur. Starting slowly and taking with food can significantly reduce nausea in the early weeks.
- Are there drug interactions with Naltrexone / Bupropion (LDN)?
- Do not take with opioid medications — naltrexone will block their effect and can precipitate withdrawal. Bupropion interacts with MAOIs (allow 14 days between), certain antidepressants, and medications that lower the seizure threshold. Avoid alcohol.
- How should I store Naltrexone / Bupropion (LDN)?
- Store at room temperature, away from heat, moisture, and direct light. Keep in the original container with the lid tightly closed.
- What precautions should I know about Naltrexone / Bupropion (LDN)?
- Do not take if you have uncontrolled high blood pressure, seizure disorder, or if you are currently using opioids. Keep out of reach of children.
- Where can I get compounded Naltrexone / Bupropion (LDN)?
- Naltrexone / Bupropion (LDN) is available through licensed compounding pharmacies on the SlimionRX network. Visit slimionrx.com to find a pharmacy near you.