Where can I get compounded Compounded Naltrexone HCl 3 mg (Sublingual)?

Compounded Naltrexone HCl 3 mg (Sublingual) is available through licensed compounding pharmacies on the SlimionRX network. Visit slimionrx.com to find a pharmacy near you.

Compounded Naltrexone HCl 3 mg (Sublingual) 3 mg / mL — Compounded Sublingual Liquid Patient Monograph

Patient education monograph for Compounded Naltrexone HCl 3 mg (Sublingual) (3 mg / mL), a compounded sublingual liquid. Learn how it works, how to use it, possible side effects, and find a licensed compounding pharmacy near you.

What is Compounded Naltrexone HCl 3 mg (Sublingual)?

This compounded preparation contains naltrexone hydrochloride 3 mg per mL in a sublingual liquid base, prepared by a licensed compounding pharmacy pursuant to a valid individual patient prescription. It is intended for low-dose naltrexone (LDN) protocols where very low starting doses (0.5 mg–1.5 mg) or precise intermediate doses are required for provider-directed immune modulation, pain support, or inflammatory condition management. Compounded naltrexone is not an FDA-approved LDN product. Formula developed in partnership with Richie's Specialty Pharmacy.

How does Compounded Naltrexone HCl 3 mg (Sublingual) work?

At very low doses (typically 0.5–4.5 mg), naltrexone transiently blocks opioid receptors for 4–6 hours, triggering a compensatory rebound increase in endogenous endorphins and enkephalins — believed to reduce systemic inflammatory signaling and modulate immune function through toll-like receptor 4 (TLR4) antagonism. The 3 mg/mL concentration allows precise dose measurement at the lowest therapeutic LDN range (0.1–1.5 mg doses), particularly useful for slow titration in sensitive patients or pediatric protocols. Sublingual delivery enhances bioavailability compared to oral tablets.

How to use Compounded Naltrexone HCl 3 mg (Sublingual)

Use at bedtime or as directed by your prescriber. Draw up the exact dose using the oral syringe provided. Place under the tongue and hold for at least 60 seconds before swallowing. Do not take within 4–6 hours of any opioid medication. Follow your prescriber's titration schedule — LDN protocols often begin at very low doses (0.5 mg or less) and increase gradually over weeks.

Compounded Naltrexone HCl 3 mg (Sublingual) side effects

Vivid or unusual dreams and mild sleep disruption are the most commonly reported effects during initiation and typically resolve within 2–4 weeks. Mild transient nausea and headache may occur, particularly at start-up. GI effects at these low doses are generally minimal. Contact your prescriber if sleep disruption or nausea is persistent or significantly affects daily function.

Drug interactions with Compounded Naltrexone HCl 3 mg (Sublingual)

Do not take within 4–6 hours of any opioid medication — naltrexone at any dose will block opioid receptor effects and can precipitate withdrawal in opioid-dependent individuals. Discuss with your prescriber if you take immunosuppressant medications, as LDN may affect immune system activity. Do not combine with full-dose opioid therapies or opioid-containing pain medications.

How to store Compounded Naltrexone HCl 3 mg (Sublingual)

Refrigerate or store at controlled room temperature as directed by your pharmacy. Protect from light and heat. Keep tightly closed. Use within the beyond-use date on the label. Use an oral syringe for accurate dose measurement — do not estimate volume.

Precautions for Compounded Naltrexone HCl 3 mg (Sublingual)

Do not use if you are currently dependent on opioid medications — naltrexone at any dose will block opioid effects. Consult your prescriber before stopping or adjusting the dose. Do not drive if drowsiness occurs after administration. This preparation contains a very low concentration (3 mg/mL) — use an oral syringe for accurate dose measurement. Keep out of reach of children.

Frequently Asked Questions — Compounded Naltrexone HCl 3 mg (Sublingual)

What is Compounded Naltrexone HCl 3 mg (Sublingual)?: This compounded preparation contains naltrexone hydrochloride 3 mg per mL in a sublingual liquid base, prepared by a licensed compounding pharmacy pursuant to a valid individual patient prescription. It is intended for low-dose naltrexone (LDN) protocols where very low starting doses (0.5 mg–1.5 mg) or precise intermediate doses are required for provider-directed immune modulation, pain support, or inflammatory condition management. Compounded naltrexone is not an FDA-approved LDN product. Formu
How does Compounded Naltrexone HCl 3 mg (Sublingual) work?: At very low doses (typically 0.5–4.5 mg), naltrexone transiently blocks opioid receptors for 4–6 hours, triggering a compensatory rebound increase in endogenous endorphins and enkephalins — believed to reduce systemic inflammatory signaling and modulate immune function through toll-like receptor 4 (TLR4) antagonism. The 3 mg/mL concentration allows precise dose measurement at the lowest therapeutic LDN range (0.1–1.5 mg doses), particularly useful for slow titration in sensitive patients or pedi
How do I use Compounded Naltrexone HCl 3 mg (Sublingual)?: Use at bedtime or as directed by your prescriber. Draw up the exact dose using the oral syringe provided. Place under the tongue and hold for at least 60 seconds before swallowing. Do not take within 4–6 hours of any opioid medication. Follow your prescriber's titration schedule — LDN protocols often begin at very low doses (0.5 mg or less) and increase gradually over weeks.
What are the side effects of Compounded Naltrexone HCl 3 mg (Sublingual)?: Vivid or unusual dreams and mild sleep disruption are the most commonly reported effects during initiation and typically resolve within 2–4 weeks. Mild transient nausea and headache may occur, particularly at start-up. GI effects at these low doses are generally minimal. Contact your prescriber if sleep disruption or nausea is persistent or significantly affects daily function.
Are there drug interactions with Compounded Naltrexone HCl 3 mg (Sublingual)?: Do not take within 4–6 hours of any opioid medication — naltrexone at any dose will block opioid receptor effects and can precipitate withdrawal in opioid-dependent individuals. Discuss with your prescriber if you take immunosuppressant medications, as LDN may affect immune system activity. Do not combine with full-dose opioid therapies or opioid-containing pain medications.
How should I store Compounded Naltrexone HCl 3 mg (Sublingual)?: Refrigerate or store at controlled room temperature as directed by your pharmacy. Protect from light and heat. Keep tightly closed. Use within the beyond-use date on the label. Use an oral syringe for accurate dose measurement — do not estimate volume.
What precautions should I know about Compounded Naltrexone HCl 3 mg (Sublingual)?: Do not use if you are currently dependent on opioid medications — naltrexone at any dose will block opioid effects. Consult your prescriber before stopping or adjusting the dose. Do not drive if drowsiness occurs after administration. This preparation contains a very low concentration (3 mg/mL) — use an oral syringe for accurate dose measurement. Keep out of reach of children.
Where can I get compounded Compounded Naltrexone HCl 3 mg (Sublingual)?: Compounded Naltrexone HCl 3 mg (Sublingual) is available through licensed compounding pharmacies on the SlimionRX network. Visit slimionrx.com to find a pharmacy near you.