Low Dose Naltrexone (LDN) 1.5–4.5 mg — Compounded Capsule Patient Monograph
Patient education monograph for Low Dose Naltrexone (LDN) (1.5–4.5 mg), a compounded capsule. Learn how it works, how to use it, possible side effects, and find a licensed compounding pharmacy near you.
What is Low Dose Naltrexone (LDN)?
This compounded preparation contains naltrexone at a low dose, prepared by a licensed pharmacy pursuant to an individual patient prescription.
How does Low Dose Naltrexone (LDN) work?
At low doses, naltrexone transiently blocks opioid receptors for a few hours, triggering a rebound increase in endorphins and enkephalins. This is believed to reduce systemic inflammation and modulate immune function, potentially benefiting autoimmune and neurological conditions.
How to use Low Dose Naltrexone (LDN)
Take exactly as prescribed, typically at bedtime. Do not take within 4 hours of opioid medications. Ask your pharmacist if you have questions.
Low Dose Naltrexone (LDN) side effects
Vivid or unusual dreams are the most commonly reported side effect, especially in the first few weeks, and usually resolve with time. Mild insomnia at initiation and transient fatigue may occur. GI effects at these low doses are rare.
Drug interactions with Low Dose Naltrexone (LDN)
Do not take within 4–6 hours of any opioid medication — naltrexone blocks their effect and can precipitate opioid withdrawal. Discuss with your prescriber if you take immunosuppressant medications, as LDN may modulate immune function.
How to store Low Dose Naltrexone (LDN)
Store at room temperature in a dry place, away from light and moisture.
Precautions for Low Dose Naltrexone (LDN)
Do not use if you are taking full-dose opioid medications. Consult your prescriber before stopping or adjusting the dose. Keep out of reach of children.
Frequently Asked Questions — Low Dose Naltrexone (LDN)
- What is Low Dose Naltrexone (LDN)?
- This compounded preparation contains naltrexone at a low dose, prepared by a licensed pharmacy pursuant to an individual patient prescription.
- How does Low Dose Naltrexone (LDN) work?
- At low doses, naltrexone transiently blocks opioid receptors for a few hours, triggering a rebound increase in endorphins and enkephalins. This is believed to reduce systemic inflammation and modulate immune function, potentially benefiting autoimmune and neurological conditions.
- How do I use Low Dose Naltrexone (LDN)?
- Take exactly as prescribed, typically at bedtime. Do not take within 4 hours of opioid medications. Ask your pharmacist if you have questions.
- What are the side effects of Low Dose Naltrexone (LDN)?
- Vivid or unusual dreams are the most commonly reported side effect, especially in the first few weeks, and usually resolve with time. Mild insomnia at initiation and transient fatigue may occur. GI effects at these low doses are rare.
- Are there drug interactions with Low Dose Naltrexone (LDN)?
- Do not take within 4–6 hours of any opioid medication — naltrexone blocks their effect and can precipitate opioid withdrawal. Discuss with your prescriber if you take immunosuppressant medications, as LDN may modulate immune function.
- How should I store Low Dose Naltrexone (LDN)?
- Store at room temperature in a dry place, away from light and moisture.
- What precautions should I know about Low Dose Naltrexone (LDN)?
- Do not use if you are taking full-dose opioid medications. Consult your prescriber before stopping or adjusting the dose. Keep out of reach of children.
- Where can I get compounded Low Dose Naltrexone (LDN)?
- Low Dose Naltrexone (LDN) is available through licensed compounding pharmacies on the SlimionRX network. Visit slimionrx.com to find a pharmacy near you.